Expression of mitotic arrest deficient-2 protein in squamous cell carcinoma tissues from head and neck
ZHANG Feng
WANG Dan
Abstract：Objective To study the expression of mitotic arrest deficient-2 ( MAD2 ) in squamous cell carcinoma ( HNSCC) tissues from head and neck .Methods The MAD2 in 101 HNSCCs tissues and tumor adjacent tissues from 101 patients with HNSCC head and neck , neck muscles from 49 human normal were observed using immunohistochemistry .Re-sults The positive expression rates of MAD 2 in tumor tissues , para-carcinoma muscular tissues and normal head and neck-muscles were 90.1%, 53.5%and 46.9%respectively;there were significant differences between the former and the latter two(P<0.05).The positive rate of MAD2 in HNSCC tissues with/without local lymph node metastasis was 98.3% and 81.4%(P<0.05).Conclusion The positive expression rate of MAD2 has increased in HNSCC tissues.MAD2 may play an important role in the initiation and development of HNSCC .
Keywords：squamous cell carcinomahead and neck squamous cell carcinomamitotic arrest deficient proteinchro-mosome instability
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 80-81 )