Effect of blood purification on the level of FGF23 in patients with chronic renal failure
DU Yi
QIAN Bai-yin
KE Jian-ting
ZHU Li-juan
WEI Yu-ting
LI Mi
Abstract：Objective To investigate the changes of FGF 23 levels in patients which chronic renal failure before and after blood purification .Methods 80 patients were recruited with maintenance hemodialysis duration >3 months.Ac-cording to the mode of blood purification treatment , the patients were divided into three groups:which were HD ( three times a week for HD), HD+HDF(twice a week for HD, once a week for HDF), and HD+HP(twice a week for HD, once a week for HD+HP) randomly based on treatment mode of blood purification as eight weeks .FGF23, PTH, 1,25(OH)2D3 and SCr, BUN, Ca, P in fasting venous blood were determined when beginning and finishing the experiment in test group . The above-mentioned indexes were also detected in venous blood collected on empty stomach in control group .Results FGF23, PTH, SCr, BUN, Phosphate in test group before blood purification was obviously higher than the control group , and the level of 1,25(OH)2D3 was lower(P<0.05).FGF23 of the test group had a positive correlation with PTH , BUN, SCr, phosphate and dialysis period(r were 0.544, 0.379, 0.318, 0.408, 0.3, P<0.05).The level of serum FGF23 was that the independent factor which affected the level of P , BUN and PTH, they had statistical significance .Before and after treament, both the group of HD+HDF and HD+HP had statistical significance in the level of FGF 23 and PTH.Con-clusions The level of FGF23 distinctly elevates in the patients with chronic renal failure , and has a positive correlation with PTH, BUN, SCr, phosphate and dialysis period .The high level of FGF23 declines sharply after HD+HDF and HD+HP procedure .
Keywords：fibroblast growth factor 23parathyroid hormonehemodialysishemodiafiltrationhemoperfusion
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 51-54 )