Correlation between HOXC9 protein expression in tissues of neuroblastoma and development as well as prognosis of the tumor
ZHU Yong-jie
CHEN Xin
BING Chun-mei
ZHANG Lin
DONG Qian
Abstract：Objective To explore the correlation between the expression of homeobox genes ( HOX) C9 protein in neuroblastoma of children and the development as well as prognosis of tumor .Methods Collected specimens of surgical tumor tissues from 112 cases with neuroblastoma , to observe the expression of HOXC 9 protein by assay of immunohisto-chemical staining and analyze the association between the expression and clinicopathological feature of neuroblastoma .Fol-lowed up with 78 children, then established the survival curve with method of Kaplan-Merier and certificated the expression quantity of HOXC9 protein and survival time in children .Results The level of HOXC9 protein expression in neuroblasto-ma was associated with several factors , such as age of child , clinical tumor-node-metastasis stage , cell differentiation grade and metastasis status(all P<0.05).Expression of HOXC9 protein was identified correlated with survival time of children in neuroblastoma(P<0.01).Conclusion HOXC9 protein is in association with the development and prognosis of neuro-blastoma.
Keywords：neuroblastomahomeobox genehomeobox genes C 9 protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )