Expression of hypoxia-inducible factor-1αand signal transducer and activator of transcription 3 and its association with prognosis of gastric cancer
CHEN Chang-rong
XU Gui-fang
ZHOU Zhi-hua
GUAN Wen-xian
WANG Hao
SUN Qi
XU Xin-yun
ZHANG Wei-jie
Abstract：Objective To investigate the relationship between expression of hypoxia-inducible factor-1α(HIF-1α) and signal transducer and activator of transcription 3(STAT3) in gastric cancer tissue and analyze their prognostic value .Methods The ex-pression of HIF-1αand STAT3 in 123 gastric cancer patients who underwent radical resection and 53 cases of control with normal gas-tric tissue were examined by immunohistochemistry.Results The positive protein expression rates of HIF-1αand STAT3 in the gas-tric cancer tissue were 64.2%(79/123) and 62.6%(77/123), which were significantly higher than those in the normal tissue 39.6%(21/53) and 43.4%(23/53)(all P<0.05).The proteins expression of HIF-1αand STAT3 were in correlation with the degree of dif-ferentiation, TNM staging, lymph node metastasis, vessel invasion and invasion depth(P<0.05), and the co-expression rates of HIF-1αand STAT3 were correlated with the TNM stages(r=0.377, P<0.05).In gastric cancer tissue, the expression of HIF-1αwas positively correlated with the expression of STAT3 (r=0.335, P<0.05).The 5-year survival rate of patients with positive ex-pression of HIF-1αand STAT3 were 21.9%and 27.4%, which were significantly lower than those with negative expression(all P<0.05), whose 5-year survival rates were 51.2%and 41.5%.HIF-1αexpression were independent prognostic factors for gastric cancer (RR=2.162, P<0.05).Conclusions In gastric cancer tissue, the expressions of HIF-1αand STAT3 are elevated and positively correlated.Patients with positive expression of HIF-1αand STAT3, the prognosis are poor.Expression of HIF-1αand TNM staging are useful for predicting the prognosis of patients with gastric cancer .
Keywords：gastric neoplasmgastric cancerhypoxia-inducible factor-1αsignal transducer and activator of tran-scription 3
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 5-7 )