Effect of Aurora A inhibitor VX-680 on chemosensitivity in human cervical cancer cell
HUA Fang
LI Qin
SONG Fei-fei
XIE Lei
LI Yi-fei
GE Jing
RU Xiu-li
LIU Jing
LI Yue-ping
Abstract：Objective To explore the effect of Aurora A inhibitor VX-680 on the treatment efficacy of Cisplatin for cervical cancer.Methods Aurora A inhibitor VX-680 was used to down regulated Aurora A in cervical cancer cell line Caski.After treated with different dose of Cisplatin, Aurora A expressions were detecfed by western Blot, cell growth and apoptosis were detected by flow cytometry.Results Down-regulation of Aurora A expression by VX-680 increased the cell inhibition and apoptosis when cells were treated with Cisplatin.Conclusion There is a positive relationship between Auro-ra A expression and chemosensitivity in cervical cancer cell, suggesting that inhibiting Aurora A expression may enhance the treatment efficacy of Cisplatin for cervical cancer.
Keywords：cervical cancerVX-680Aurora ACisplatin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 11-13 )