Relation of intestinal immunologic barrier function with volume and malnutrition status in uremic patients
WANG Zun-song
CUI Mei-yu
TANG Li-jun
LI Wen-bin
WEI Yong
XU Dong-mei
Abstract：Objective To evaluate intestinal immunologic barrier function in uremic patients and its relationship with volume and malnutrition status.Methods Sixty uremic patients without hemodialysis, sixty uremic patients undergoing hemodialysis, and thirty healthy people in control group were recruited for this study.Enzyme-linked immunosorben assay ( ELISA) was used to analyze feces secretory immunoglobulin A ( sIgA) to evaluate intestinal immunologic barrier function, fluid status [ evaluated by the inferior vena cava diameter ( IVCD) and the collapsibility index ( CI) ] was measured by B-mode ultrasonic diagnostic equipment.Modified quantitative subjective global assessment ( MQSGA) was used to evaluate nutritional status.The relationship among sIgA, CI, IVCD and MQSGA was assessed.Results The amounts of feces sIgA were significantly lower in hemodialysis group and no-hemodialysis group than those of control group (all P<0.01).The measurements of IVCD were significantly higher in hemodialysis group and no-hemodialysis group than those of control group (all P<0.01).No significant difference of the measurements of IVCD between no-hemodialysis and dialysis group was found.Linear regression was found between sIgA and IVCD, b=-0.264,P<0.01.Negative correlation was found between sIgA and MQSGA, r=-0.591, P<0.01.Conclusions In uremic patients, whether hemodialysis or without hemodialysis, intestinal immunologil barrier is damaged, blood volume is overloaded.The injury degree of intestinal immu-nologic barrier is associated with volume status and nutritional status.
Keywords：renal failureimmunological barriersecretory immunoglobulin Avolume load
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3-5 )