Influence of MDRl, CYP3A genetic polymorphisms on serum digoxin concentration in Uygurs and Hans nationality patients with heart failure
FAN Yin-wen
YAN Jian-feng
HE Zhou-bin
WU Jing-jing
SUN Shuai
ZHANG Xuan
PA Ti-man
YANG Li-jie
Abstract：Objective To investigate the effects of MDR1 C3435T and CYP3A4*18B polmorphisms on serum digoxin concentration in Uygurs and Hans nationality patients with heart failure.Methods 40 Uygur nationality patients and 40 Han nationality patients with heart failure were included in this study, the genetyping of MDR1 C3435T and CYP3A4*18B were determined by the polymerase chain reaction with the restriction fragment length polymorphism ( PCR-RFLP) , and to analysis the digoxin concentration by genetic polymorphisms.Results The serum digoxin concentration of MDR1 C3435T genetypes CC group and TT group in Han nationality patients were obviously higher than the same genotype groups in Uygurs nationality patients (all P<0.05).The CYP3A4*18B genetic polymorphism had no significant difference between two groups (P>0.05).Conclusions The serum digoxin concentration is effected by MDR1 C3435T genetic polymor-phism in Han nationality patients with heart failure, but without effect on Uygurs nationality patients with heart failure. CYP3A4*18B genetic polymorphism may have no significant effects on the serum digoxin concentration in two nationalities patients with heart failure.
Keywords：pharmacogeneticsdigoxinMDR1CYP3A4Uygur nationalityHans nationality
Publication Date：2014-01-01
Pages：3( 13-15 )