Association of gene polymorphism of CCL3 and CCL4 with tuberculosis susceptibility
ZHANG Jian-wu
XING Zhi-wei
LI Xin
SUN Zhi-ping
SUN Hong-mei
JIA Jian-lei
Abstract：Objective To explore the relationship of CCL3-2021C/T and CCL4-5725A/C gene polymorphisms with susceptibility to tuberculosis ( TB) .Methods 78 TB patients and 97 healthy controls were included in the study.CCL3-2021C/T and CCL4-5725A/C were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in two groups.Results CC, CT and TT genotype frequency of CCL3-2021C/T were 2.5%, 15.4%, 82.1% in TB group and 0, 18.6%, 81.4%in control group (all P>0.05).C allele frequency was 10.2%and T allele frequency was 89.8%in TB group;which were 9.3%and 90.7%in control group (all P>0.05).AA, AC and CC gen-otype frequency of CCL4-5725A/C were 7.7%, 30.8%, 61.5% in TB group and 5.2%, 27.8%, 67.0% in control group (all P>0.05).A allele frequency was 23.1%and C allele frequency was 76.9%in TB group, which were 19.1%and 80.9%in control group (all P>0.05).Conclusion Single nucleotide polymorphism (SNP) of CCL3-2021C/T and CCL4-5725A/C maybe not related to the susceptibility of TB infection.
Keywords：tuberculosischemokinesCCL3CCL4gene polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )