Changes of MMPs and IL-1βin serum and cerebrospinal-fluid in children with central nervous system infection
WANG Yan-ping
XU Xiao-hua
HUA Ying
JING Miao
Abstract：Objective To explore the role of matrix metalloproteinases 9 ( MMP-9 ) and interleukin 1 in the central nervous system infection and investigate the significance.Methods The levels of MMP-9 and IL-1βin serum and cerebro-spinal fluid( CSF) of 20 purulent meningitis children( PM) , 30 viral encephalitis children( VE) , 30 acute non-central sys-tem infection children( control) were measured by ELISA.The level of serum albumin( SAlb ) was arrayed by automatic bio-chemical analyzer, and CSF albumin(CAlb) was detected by immunonephelometry to count AQ.Results The levels of MMP-9 in the serum of PM, VE and control were (489.98 ±159.09), (267.85 ±91.89) and (133.03 ±31.64)μg/L. The levels of IL-1βin serum of PM, VE and control were (21.35 ±4.91), (19.57 ±5.70) and (14.07 ±3.94)ng/L. The levels of MMP-9 in CSF of PM, VE and control were (116.8 ±41.78), (37.19 ±17.87) and (10.25 ±5.33)μg/L.The levels of IL-1βin CSF of PM, VE and control were (106.28 ±12.83), (66.95 ±10.63) and (49.97 ±12.57) ng/L.The levels of MMP-9, IL-1βin serum and CSF were significantly higher in PM and VE compared with the control(P<0.05).The levels of MMP-9, IL-1βalso showed significantly different between PM and VE(all P<0.05) except for IL-1βin serum.SAlb in PM, VE and control were (38.75 ±2.73), (39.57 ±3.95) and (39.37 ±4.14)g/L.There was no significant difference among the three groups(all P>0.05).CAlb in PM, VE and control were (1.04 ±0.28), (0.54 ±0.14) and (0.18 ±0.08)g/L.AQ were 26.97 ±7.29, 13.76 ±3.45 and 4.61 ±2.05.CAlb and AQ were significantly different among the three groups(P<0.05).There was a positive correlation between MMP-9 and IL-1βin serum(r=0.304, P<0.01) and CSF(r=0.834, P<0.01) in PM and VE.Conclusions The levels of MMP-9 and IL-1βin ser-um and CSF, CAlb and AQ increase in children with central nervous system infection.MMP-9 and IL-1βmay participate in the pathophysiologic course of blood-brain barrier impairment in the central nervous system infection.
Keywords：central nervous system infectionpurulent meningitisviral encephalitismatrix metalloproteinases 9in-terleukin 1blood-brain barrier
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 23-26 )