Observation on vascular endothelial function and metabolic function in impaired fasting glucose combining impaired glucose tolerance
LV Yi-pei
HUANG Wen-ping
CHE Hong-ying
ZHANG Su-hua
HUANG Zhong-ying
CHEN Jian-xi
YANG Pi-jian
LI Shu-min
LU Wei-bo
HUANG Hong
Abstract：Objective To investigate the vascular endothelial function and metabolic function in patients with im-paired fasting glucose combining impaired glucose tolerance( IFG+IGT) .Methods 72 cases of IFG+IGT( group E) in-cluding 42 cases of obesity(group E2)and 30 cases of no-obesity(group E1) were compared to 142 cases of normal glucose tolerance(group N) including 67cases of obesity(groupN2) and 75 cases of no-obesity(group N1).Glucose and insulin were detected in all cases by oral glucose tolerance test and insulin release test.Fasting venous blood of all samples were obtained to measure fasting lipid-related indicators by automatic biochemical analyzer.Serum endothelin-1(SET) was de-tected by RIA and high-sensitivity C-reactive protein( hs-CRP) was detected by immunoturbidimetry.The urine endothelin-1( UET) was tested by no extract direct method of RIA, and urea-microalbumin( MUA) was tested by nephelometry after collecting urina sanguinis.The brachial artery diameter at basal( Db) , reactive hyperemic( Dh) and sublingual nitroglycer-in( Dn) conditions were measured by color Doppler ultrasound respectively.The blood pressure and waist, calculated endo-thelium-dependent vasodilatation ( EDD, ΔD%) and endothelium-independent vasodilatation ( EID, ΔD1%) were also measured respectively.Results The differences of MUA, Hs-CRP, SET, UET,ΔD%andΔD1%after adjusting for sex and age were all significant between group E and group N, group E2 and group N2, group E1 and group N1 ( all P<0.05).It was significant difference between group N2 and group N1 in Hs-CRP, SET and UET(all P<0.05).It was also significant difference between group E2 and group E1 in MUA, Hs-CRP, SET and UET(all P<0.05).Conclusions The impaired endothelial function which occures in macrovascular and microvascular is found in the patients with IFG and IGT and it is serious in the cases of obese patients.The patients with IFG and IGT occure metabolic dysfunction mainly inclu-ding hypertension, hyperglycemia, dyslipidemia, insulin resistance and decline of insulin secretion.
Keywords：impaired fasting glucoseimpaired glucose toleranceobesityendothelial functionmetabolic function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 19-22,26 )