Expression and clinical significance of Apaf-1 and Caspase-9 in basal-like breast carcinoma
ZHANG Bing-xin
ZHAO Xia
CHEN Xue
ZHOU Bing-juan
ZHAO Wen-ming
LI Jin-mei
SUN Ji-rui
ZHANG Jin-ku
Abstract：Objective To observe the changes of Apaf-1, Caspase-9 expression in the basal-like breast cancer ( BLBC) tissues and explore its clinical significance.Methods The expressions of Apaf-1 and Caspase-9 were detected in 43 cases of BLBC( group A) , 57 cases of non-BLBC( group B) and 60 cases of normal breast tissue( group C) by immuno-histochemistry.The relationship between Apaf-1, Caspase-9 expression and clinicopathological features were analyzed.The correlation between Apaf-1 and Caspase-9 expression was analyzed.Results The positive expression rate of Apaf-1 in group A, B, C was 23.3%(10/43), 49.1%(28/57), 75%(45/60) respectively.The difference between each group was significant(all P<0.01).The positive expression rate of Caspase-9 in group A, B, C was 27.9%(12/43), 54.4%(31/57), 85%(51/60) respectively.The difference between each group was all significant(all P<0.01).The expres-sion of Apaf-1 was significantly correlated with the size of tumor, lymph nodes metastasis and the tumor clinical stage( all P<0.05) .The expression of Caspase-9 was significantly correlated with lymph nodes metastasis and the tumor clinical stage (all P<0.05).There correlation between the expression of Apaf-1 and Caspase-9 was significant(r=0.636, P<0.01). Conclusions Apaf-1 and Caspase-9 are lower expressed in BLBC.The abnormal expression of Apaf-1 and Caspase-9 may be closely correlated with the carcinogenesis and development of BLBC.
Keywords：breast neoplasmsbasal-like breast cancerapoptotic protease activating factor 1Caspase-9
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )