Efficacy of the prevention of postoperative early onset atrial fibrillation by earlier application of rosuvastatin in coronary artery bypass grafting:a Meta analysis
YU Bo
AI Fen
Abstract：Objective To systematically review the efficacy of the prevention of postoperative early onset atrial fibril-lation by earlier application of rosuvastatin in coronary artery bypass grafting(CABG).Methods Articles about relevant randomized controlled trials ( RCTs) were electronically searched from BMA, EMbase, ASP, the cochrane library, EMCC, Pubmed, CBM, CNKI, CECDB, CQVIP, and VIP databases published during January 2004 to January 2014.The quality of the included studies was treated with strict appraisal and data extraction.Then, meta-analysis was performed by using Stata/SE version 12 software to analysis all the articles.Results Eventually, 7 articles of RCT were included involving 1 479 cases of patients, of which, 790 cases were treated with rosuvastatin 10 or 20 mg before CABG operation( treatment group) , 689 cases were treated with placebo before operation( control group) .The results of meta analysis demonstrate that compared with control group, early postoperative morbidity of atrial fibrillation reduced in treatment group in both 10 and 20 mg dose rosuvastatin [RR was 0.70 and 0.65, respectivly;95%CI was (0.55, 0.90) and (0.51, 0.83), respectively;P was 0.407 and 0.770, respectively].Conclusions Earlier application of rosuvastatin before CABG can effectively re-duce the probability of postoperative early onset atrial fibrillation.
Keywords：coronary artery bypass graftingatrial fibrillationrosuvastatin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 48-51 )