Expression of SDF-1 and CXCR4 in triple negative breast cancer tissues and its relationship with prognosis
KONG Ling-yu
FU Qin-ye
Abstract：Objective To investigate the expression and clinical significance of stromal cell derived factor-1 ( SDF-1) and its receptor stromal cell derived factor receptor-4 ( CXCR4) in triple negative breast cancer( TNBC) tissue.Methods The expression of SDF-1 and CXCR4 of 77 TNBC cases were detected by using immunohistochemistry.The correlation between SDF-1/CXCR and clinical pathological features and prognosis were assessed.Results The expression rate of SDF-1 and CXCR4 in TNBC tissues was 41.6%, 64.9%, respectively.The expression rate of SDF-1 and CXCR4 in TN-BC tissues were significantly correlated (P=0.041).The high expression of SDF-1 and CXCR4 were not correlated with age, tumor size, clinical stage and histological grade(P>0.05), but obviously correlated with lymph node metastasis(PS-DF-1=0.021,PCXCR4=0.010) and disease free survival(PSDF-1=0.023,PCXCR4=0.015).COX regression multi-variate analysis showed that SDF-1 was an independent prognostic factor of disease free survival in TNBC(OR=2.318, 95%CI=1.028-5.230).Kaplan-Meier survival analysis indicated that time of disease free survival was shorter in SDF-1 and CXCR4 high expression patients than that in low expression patients(PSDF-1=0.011,PCXCR4=0.018).Conclu-sions The expression of SDF-1 and CXCR4 in TNBC tissues can be used as important biomarkers of the prognosis.
Keywords：triple negative breast cancerstromal cell derived factor-1cell derived factor receptor-4disease free survival
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 22-25 )