Feasible of muscle flap repairing partal cervical esophagus defect with inner chitosan tubular scaffolds
LIU Jia-bao
ZHENG Zhi-min
CHU Wei-wei
ZHANG Ya-xiao
ZHAO Xiao-jian
WANG Ren-feng
CHEN Gang
Abstract：Objective To investigate the feasibility of muscle flap repairing partal cervical esophagus defect with inner chitosan tubular scaffolds.Methods A totoal of 21 rabbits were made partial cervical esophagus defect models, with inner chitosan tubular scaffolds set in breakage, extrinsic muscle flap repaired.Postoperative animal body weight change was ob-served.Three rabbits were sacrificed at 4,8 and 12 weeks later, respectively.Esophagus defect was observed under the na-ked eye and optical microscopy.Esophagus stenosis and peristalsis were observed by esophageal barium at 16 weeks later. Results There were 18 animals survived after operation.At the first four weeks, muscle flap tissues healed well, chitosan tube unabsorbed, with no inflammatory response was observed under light microscope.At eight weeks later, chitosan tube partially absorbed, muscle flap blood supply good, no fibrous tissue hyperplasia.At 12 weeks later, chitosan tube was com-pletely absorbed, inside muscle flap surface mucosal regeneration with no stenosis.At 16 weeks later, esophagus barium was found smooth without stenosis, and peristalsis was weak.Conclusions It was feasible that muscle flap repairing partal cervical esophagus defect with inner chitosan tubular scaffolds.
Keywords：chitosanscaffoldsmuscle flapesophageal defectesophageal reconstruction
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 15-17 )