Serum microRNA-9 level changes and it′s significance in Alzheimer′s disease patient
XIAO Jian-ting
YU Yang
TAN Lan
MIAO Dan
Abstract：Objective To investigate the value of serum MicroRNA-9 ( miR-9 ) in the early diagnose of Alzheimer′s disease(AD).Methods Serum samples were obtained from 75 old AD patients(case group) whose minimum mental state examination(MMSE) scored 13.27 ±2.53 and 85 old normal controls(normal group) to detected miR-9 level by the meth-od of real-time quantitative reverse transcriptase PCR ( qRT-PCR) .The clinical diagnosis value was evaluated by receiver operating characteristic( ROC) result to analyze it′s sensitivity and specificity.Results Compared with normal group, ser-um MiR-9 level of case group decreased significantly (P=0.012).The sensitivity and specificity in the diagnosis of AD was 80.5%and 71.8%, respectively.MiR-9 was negatively correlated with MMSE score (r=-0.603, P<0.01).Con-clusions Serum miR-9 can be used as an early diagnose biomarker for AD.
Keywords：alzheimer′s diseasemicroRNAserumbiomarker
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )