Changes of serum copeptin in patients with acute exacerbation of chronic obstructive pulmonary disease
JING Jun-hu
LI Li-yu
LI Jian-qiang
Abstract：Objective To explore the levels and clinical significance of copeptin in acute exacerbation of chronic ob -structive pulmonary disease (AECOPD).Methods 90 subjects with AECOPD were divided into on respiroatory faicure group (n=43), respiratory failure group (n=47),and forty healthy as a control group .The levels of serum copeptin of all AECOPD patients before and after treatment and control group were detected .Results Before treatment , the serum copep-tin of the respiratory failure group was(25.31 ±16.33)pmol/L, on respiroatory faicure group was(10.34 ±4.37)pmol/L, all of them were higher than the control group (4.93 ±1.20)pmol/L (all P<0.01),and the respiratory failure group was higher than the no respiratory failure group (P<0.01);after treatment, the serum copeptin of the respiratory failure group was(5.93 ±3.37)pmol/L, on respiroatory faicur group was (5.47 ±1.60)pmol/L,all of them were significantly reduced (P<0.01).Conclusion The levels of serum copeptin is significantly increased in AECOPD patients .The serum copep-tin is expected to be a useful biological index to estimate the AECOPD .
Keywords：pulmonary diseasechronicobstructiveacute exacerbationscopeptin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 19-20,23 )