Animal study of ischemia-reperfusion injury after decompression of chronic spinal cord compression
HUA Kai
GUO Qing-sheng
ZHANG Shan-yong
Abstract：Objective To study weather the existence of reperfusion injury after decompression of chronic spinal cord compression, as well as the relationship between the degree of spinal cord compression and reperfusion injury by use of ani -mal experiments .Methods Nighty-six rabbits were randomly divided into four groups , and each group was divided into two subgroups with 12 rabbits respectively .Group A was the sham operation group , group B ( the percentage of occupying area of the intraspinal lesion was 50%), group C occupying 60%, group D occupying 70%.Group B1, C1 and D1 didn't take the screws out, while group B2, C2 and D2 were removed the screws.And modified Tarlov score, MDA content, GSH-px activity assay , SOD activity assay , TUNEL-positive cell counts were detected after six hours .Results The Tarlov score of group A was significantly higher than that of group B , C and D.The Tarlov score gradually reduced in Group B 1, C1 and D1, and there was a significant difference among these groups (all P<0.05).The Tarlov scale of Group B2 and C2 was higher than that of Group B1 and C1, and there was also a significant difference among these groups .There was a relatively significant difference between Group C1, D1 and Group A1 in MDA content(P<0.05 or <0.01 ).Comparison of the ac-tivity of SOD and GSH-px, there were significantly difference between C1, D1 and A1 (P<0.05 or <0.01 ).Conclu-sions Ischemia-reperfusion injury after decompression of chronic spinal cord compression can occur , and the more severe compression spinal cord endure , the more significant reperfusion injury cause .
Keywords：spinal cord compressionischemia-reperfusion injuryrabbit
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 16-18 )