Reasons for apheresis platelet transfusion refractory on patients with blood disorder and its countermeasures

SHEN Sheng-jian; ZHAO Ming-feng; ZHANG Yu-chen

doi:10.3969/j.issn.1002-266X.2014.37.002

Abstract：Objective To explore incidence rate and influence factor of apheresis platelet transfusion refractory ( PTR) on patients with blood disorder .Methods The data of 318 infusions for 70 patients subject to apheresis platelet infusion were retrospectively analyzed , by calculating corrected Count increment ( CCI ) and percent platelet recovery ( PPR) and combining hemorrhage improvement condition in patients , the effect of platelet transfusion were determined and influence factors and treatment measures were discussed .Results ①The PTR occurrence rate of acute leukemia (AL), aplastic anemia (AA), bone marrow abnormalities syndrome (MDS) and idiopathic thrombocytopenic purpura (ITP) in patients hit 22.1%, 25.5%, 38.3%and 22.1%respectively, the difference in platelet PTR rate in four types of blood diseases was statistically significant (P<0.05).②The difference was statistically significant when the incidence rate of PTR of patients without complications was compared to that of patients with spices of diseases and complications ( P<0.05).③The incidence rate of PTR in the group of patients without complications rose with the increase in the number of infusions (P<0.05).④The difference was statistically significant when the incidence rate of PTR in the group of patients without the filtration of white blood cells was compared to that in the group of patients with the filtration of white blood cells (P<0.05).Conclusions The disease type, number of infusions, fever, infection, spleen enlargement, DIC and other factors become critical factors affecting the transfusion effect of platelets on patients with blood diseases , and the decrease in the complications and filtration of groups of white blood cells can improve the transfusion efficacy of platelets .