Effects of stellate ganglion block on intrapulmonary shunt and oxygenation during one-lung ventilation of rabbit

LIU Yang; GUO Wei; LV Na; ZHANG Jian-ping; YANG Da-wei; GUO Jian-rong

doi:10.3969/j.issn.1002-266X.2014.36.007

Abstract：Objective To observe the effects of stellate ganglion block on oxygenation and intrapulmonary shunt dur -ing one-lung ventilation ( OLV) of rabbit .Methods Healthy adult rabbits were exposed right stellate ganglion under basal anesthesia , an epidural catheter was placed and fixed .3 days later , twenty-four healthy rabbits were randomly divided into 2 groups:SGB group (n=12), 0.25%bupivacaine 0.5 mL was injected through the epidural catheter 10 min before basal anesthesia;control group (n=12), physiological saline 0.5 mL was injected through the epidural catheter .Inserting an endotracheal tube to control breathing after a tracheotomy performed , then the tube was inserted into the right bronchus un-derwent one lung ventilation .To maintain anesthesia , ECG, MAP, MPAP were continuously monitored during anesthesia . Blood samples were taken from radial artery and mixed venous blood for blood gas analysis at following intervals :the rabbit was basal anesthesia (T0), 15 min after two lung ventilation (T1), 15, 30, 60, 120 min during the course of one lung ventilation ( T2 , T3 , T4 , T5 ) and the two lungs ventilation again for 30 min ( T6 ) .Calculation of pulmonary and systemic oxygenation by formula .Results Qs/Qt was significantly increased after OLV was started , there were significant differ-ence in Qs/Qt at T3, T4 points between two groups (all P<0.05).PaO2 was significantly lower after OLV and reached the lowest level at T3 then was gradually increasing , which were significant difference in PaO 2 at T2 , T3 , T4 points between two groups (all P<0.05).MPAP in control group increased significantly at T 3, T4 compared with group SGB (P<0.05). Conclusion During OLV, general anesthesia combined SGB does not affect Qs /Qt and provide higher PaO 2 than general anesthesia , and decrease the incidence rate of hyoxemia during operation .