Effects of cell factors and its receptors in the serum on the illness change and prognosis of breast cancer patients
QIU Mei-ting
QIN Song-shu
QIN Tian
YANG Lan-ping
LI Xiao-lin
Abstract：Objective To investigate the effects of serum levels of tumor necrosis factor alpha ( TNF-α) , soluble P55 (sTNFR-P55), transforming growth factor β1(TGF-β1) and soluble CD105(s-CD105), CCL20 chemokine and chemokine receptor CXCR3 on the illness change and prognosis of breast cancer patients .Methods 53 cases of patients with breast cancer recurrence and metastasis ( observation group ) , 42 cases of breast cancer without metastasis patients ( control group) , 36 cases of breast cancer patients ( operation group ) , and 41 individuals for health physical examination ( normal group) were included in the study .The serum TNF-α, sTNFR-P55, TGF-β1 , s-CD105 , CCL20, CXCR3 levels were meas-ured and compared among groups .Results There were significant differences of the serum TNF-α, sTNFR-P55, TGF-β1 , s-CD105, CCL20, CXCR3 between operation group preoperation and normal group (all P<0.05).The serum TNF-α, sT-NFR-P55, TGF-β1 , s-CD105 , CCL20, CXCR3 levels in the observation group were higher than those in the control group and the normal group (all P<0.05).The serum TNF-α, sTNFR-P55, TGF-β1, s-CD105, CCL20, CXCR3 levels in the local recurrence cases , lymph nodes metastasis cases , distant metastasis cases of the observation group had no significant differences (all P>0.05).Conclusion The levls of TNF-α, sTNFR-P55, TGF-β1, s-CD105, CCL20, CXCR3 in serum are closely related with illness change of breast cancer .
Keywords：breast tumorcytokinereceptorrecurrencemetastasis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )