Expression and significance of IFI16, p53, p21waf1/cip in colorectal cancer
ZOU Yun-lian
ZHANG Jin-ping
GAO Jian-mei
SA Ya-lian
YANG Hui
LI Ying
YAN Xin-min
Abstract：Objective To study the expression and significance of IFI 16, p53 and p21waf1/cip in colorectal cancer tis-sues.Methods The SP immunohistochemistry method was applicated to detect the expression of IFI 16, p53 and p21waf1/cip in paraffin embedded blocks of colorectal cancer tissues .Results IFI16 was detected in nuclear and cytpoplasm of color-ectal cancer cell.The expression of IFI16 was positive correlated with p21waf1/cip (r=0.365, P<0.01), but the epitopic expression of IFI16 was negative correlated with p21waf1/cip(r=-0.298, P<0.05).There was no significant association between IFI16 and p53(P>0.05).Conclusion IFI16 might take part in the occurrence progress of colorectal cancer ac-cording to the expression and location of IFI 16 related with the p21waf1/cip .
Keywords：colorectal cancerinterferon-induced protein 16p53p21waf1/cip
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 11-13 )