Efficacy and safety of loading dose ticagrelor before PCI in patients with acute coronary syndromes
PU Chun-hua
ZHOU Peng
WANG Pei-jian
Abstract：Objective To explore the safety and efficacy of loading dose of ticagrelor and clopidogrel before percuta -neous coronary intervention (PCI) in patients with emergency acute myocardial infarction (AMI).Methods Eighty-four emergency AMI patients treated with emergency PCI in 12 hours, who were randomly divided into clopidogrel group (40 ca-ses, 600 mg loading dose) and ticagrelor group (44 cases, 180 mg loading dose) in one hour before PCI.Two groups fol-lowed by 75 mg daily thereafter.Observation time was 7 d, follow-up time was 30 d.To observe the platelet aggregation rate and postoperative TIMI flow before treatment , medication 0.5 h, 2 h, 24 h, 2 d and 7 d, and the composite endpoint and adverse events within 30 d.Results In clopidogrel group , the platelet aggregation rate in medication of 0.5 h, 2 h, 24 h was 81.28%±9.81%, 62.06%±8.80%, 59.31%±13.11%, the overall incidence of adverse reactions was 65.00%;ticagrelor group was 64.35%±11.46%, 43.73%±6.40%, 45.96%±11.90%and 20.45%;all P<0.01. Clopidogrel overall incidence of the composite endpoint events , postoperative TIMI 3 flow grade were 2.50%, 80.00%;ti-cagrelor group were 2.27%, 77.27%;both P>0.05.Conclusion Emergency AMI patients before PCI using a loading dose of ticagrelor had more significant role in the early inhibition of platelet compared with clopidogrel , and without increas-ing bleeding , lower incidence of the gastrointestinal reactions .
Keywords：acute myocardial infarctionticagrelorclopidogrelsafetyefficacy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-3,7 )