Expression and significance of VEGF, nm23 in primary tumors and lymph-node metastases in breast cancer

NING Dian-bin; ZHAO Yu-zhe; QI Hong-hui

doi:10.3969/j.issn.1002-266X.2014.35.06

Abstract：Objective To investigate the expression and significance of VEGF and nm23 in primary tumors and lymph-node metastases in breast cancer.Methods Totally 60 breast cancer patients who underwent surgery in our depart-ment during the year of 2005 and without anticancer therapy pre-surgery were selected.Postoperative pathology confirmed that there were 24 cases ( the group without metastasis) without lymph node metastasis at the ipsilateral axillary, and 36 ca-ses (the group with metastasis) with lymph node metastasis.SP immunohistochemistry was used to detect the protein ex-pressions of VEGF, nm23 and the relationship between VEGF and nm23 was analyzed.Results In the group with metas-tasis, the positive rate of protein VEGF in the primary tumor (91.7%) was higher than that in the metastases (61.1%), P<0.05.The positive rate of protein VEGF in the group with metastasis (91.7%) was higher than that without metastases (70.8%), P<0.05.In the group with metastasis, the positive rate of protein nm23 in the primary tumor (16.7%) was lower than that in the metastases (41.7%), P<0.05.The positive rate of protein nm23 in the group with metastasis (16. 7%) was lower than that without metastases (45.8%) , P<0.05.The expressions of VEGF and nm23 were negative cor-related(r=-0.415, P<0.05).The expression of VEGF and nm23 in breast primary tumor were not associated with that of lymph-node metastases.Conclusions The expression of VEGF in the breast primary tumor is significantly higher than that in the lymph-node metastases, but the expression of nm23 in the breast primary tumor is significantly lower than that in the lymph-node metastases.VEGF and nm23 are closely related with lymph node metastasis of breast cancer.They have an antagonistic effect in the development of breast cancer and lymph node metastasis.