Effect of extracts of Euphorbia esula on proliferation of human lung cancer cells A549
YANG Wen-jie
XIANG Yun-tao
CHENG Jian-hui
ZHANG Xiang-hong
MA Fan-rong
WANG Ai-hong
Abstract：Objective To investigate the inhibit proliferation and induced apotosis effects of extracts of Euphorbia esu-la in the human lung cancer cell lines A549.Methods The human lung cancer cell lines A549 were treated with different concentrations(0, 0.2, 0.4, 0.8 g/L) of extracts of Euphorbia esula in vitro, the cell proliferation was analyzed by MTT;the cell morphological changes were observed using PI dyeing;the cell apoptosis was detected by flow cytometry.Results the growth of A549 cells were inhibited by extracts of Euphorbia esula in a dose-dependent manner.A549 cells were treated with extracts of Euphorbia esula of 0, 0.2, 0.4, 0.8 g/L concentrations for 48 h, the apoptosis rates were 5.33%±0.67%, 15.53%±0.15%, 21.42%±1.01%, 46.57%±1.76%, respectively.Compared with the former, the lat-ter was higher, all P<0.05.Conclusion Extracts of Euphorbia esula can inhibit apoptosis of the A549 cells by inhibition of cell proliferation.
Keywords：extracts of Euphorbia esulalung tumorA549 cellcell apoptosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 13-15 )