Expression of VEGF and sflt-1 in endometriosis patients'ectopic endometrial tissue and eutopic endometrial tissueSHI
SHI Shu-hong
LI Yan-fang
GAO Xiu-juan
LIU Shou-juan
LI Rong-xia
LI Teng-hua
Abstract：Objective To explore the expression of vascular endothelial growth factor( VEGF) and vascular endotheli-al growth factor soluble receptor-1( sflt-1) in endometriosis patients'ectopic endometrial tissue and eutopic endometrial tis-sue.Methods Forty-six parts of ectopic endometrial tissue of ectopic group were collected in 46 patients with endometrio-sis, thirty-two parts of eutopic endometrial tissue were involved as eutopic group.Thirty parts of endometrial tissue in non-endometriosis patients were collected as control group.VEGF and sflt-1 mRNA were detected by Real-time quantitative PCR assay, the expression levels were calculated using the difference threshold algorithm.Result Expression of VEGF mRNA and VEGF activity index in eutopic group were higher than those of ectopic group and control group( all P<0.05) . Expression of VEGF mRNA in control group was higher than ectopic group(P<0.01).Expression of sflt-1 in control group was higher than eutopic group and ectopic group, which in eutopic group was higher than ectopic group(all P<0.05). Conclusions There are changes with expression of VEGF and sflt-1 in endometriosis patients'ectopic endometrial tissue and eutopic endometrial tissue.sflt-1 may be related to the pathogenesis of endometriosis.
Keywords：endometriosisangiogenesisvascular endothelial growth factorvascular endothelial growth factor soluble receptor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 18-20 )