Antibacterial action of sodium houttuyfonate and ampicillin against Staphylococcus epidermidis
JIA Fang
YANG Jiang-liu
LIU Wen-hui
XING Li-qun
Abstract：Objective To detect antibacterial action of sodium houttuyfonate and ampicillin against Staphylococcus epidermidis .Methods Two-fold dilution microdilution checkerboard and time-kill assay were utilized to evaluate drug sus-ceptibility of eight isolates .Results The MIC of sodium houttuyfonate and ampicillin alone against Staphylococcus epider -midis were 12.5-50 μg/mL and 2-64 μg/mL, respectively.After treatment of In sodium houttuyfonate combination with ampicillin, the MICs of sodium houttuyfonate and AM to SE were decreased by 8-16 and 4-8 times, fractional inhibitory concentration indices(FICI) was 0.25-0.375.The killing baceterial action of sodium houttuyfonate and ampicillin was syn-ergistic reaction.Conclusion Antibacterial action between sodium houttuyfonate and ampicillin against Staphylococcus epidermidis is synergistic in vitro .
Keywords：sodium houttuyfonatematrineampicillinStaphylococcus epidermidisMIC
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-22 )