Effects of intrauterine injection of sodium hyaluronate and oral administration of Yasmin on intrauterine adhesions after missed abortion surgery

SUN Dong-yan; LANG Yan; WANG Yan; ZOU Qian; DUAN Jie; Xiong Jun

doi:10.3969/j.issn.1002-266X.2014.31.020

Abstract：Objective To observe the effects and safety of using intrauterine injection of sodium hyaluronate and oral administration of Yasmin to alleviate intrauterine adhesions after missed abortion surgery .Methods Totally 800 patients with missed abortion undergoing curettage surgery were randomly divided into the experimental A , B, C groups and the con-trol group of 200 cases.Four groups were all given the entire superconducting visual painless curettage surgeries by the same group of high qualification physician in strict accordance with the operating rules ( premedication was compound mife-pristone and misoprostol).After the surgery, patients in the experimental group B were injected sodium hyaluronate 1 mL;patients in the experimental group C immediately took Yasmin 1 pill/d orally for 21 days.Patients in the experimental group A applied the above two methods at the same time .The surgery, the changes of menstrual flow , the incidence of intrauter-ine adhesions and adverse drug reactions of each group were observed .Results The intraoperative complications did not occur in each group and there was no significant difference in the operative time .The incidences of menstrual flow reduction and intrauterine adhesions in the experimental groups were lower than those of the control group , especially in the experi-mental group A (all P<0.05).Patients in the experimental group A and group C got the mild individual dizziness , nause-a, breast tenderness and postoperative vaginal bleeding , vaginal spotting between periods , but they all made self-improve-ment.Those groups didn′t get the weight gain.Conclusion The intrauterine injection of sodium hyaluronate combined with the oral administration of Yasmin can significantly alleviate the incidence of intrauterine adhesions after missed abortion surgery with high safety .