Expression changes and significance of Smad7 and Smad4 in squamous-cell carcinoma of the head and neck
ZHANG Feng
Abstract：Objective To observe the expression changes of Smad 4 and Smad7 protein in the squamous-cell carcino-ma of the head and neck and to evaluate the significance .Methods The expression of Smad7 protein, Smad4 protein and TGF-β1 in the squamous-cell carcinoma tissues of the head and neck , adjacent tissues and normal tissues from biopsy was detected by immunohistochemical SP method .The relationships between the three expression and with the clinicopathologi-cal parameters were analyzed .Results ①The expression of TGF-β1 and Smad7 in the tumor tissues was higher than that in the adjacent tissues and normal tissues (F=5.71 and 7.31, respectively), but the expression of Smad4 was significant-ly lower than that of the adjacent tissues and normal tissues (F=14.92), all P<0.05.② With the increase of the de-grees of tumor differentiation , the expression of TGF-β1 and Smad7 protein showed a decreased tendency ( F =11.2, 12.8), while the expression of Smad4 protein showed an increased tendency (F=7.91), all P<0.05.The Smad4 ex-pression was negatively correlated with the diameter of tumor , and Smad7 expression was positively correlated with the di-ameter of tumor (all P<0.05), but no significant correlation was found between the expression of TGF-β1 and diameter of tumor (P>0.05).The expression of the Smad4 protein in lymph node metastasis group was significantly lower than that in non-metastasis group (P<0.05), and there was no significant difference in the expression of Smad 7 and TGF-β1 between the two groups (P>0.05).③The Smad4 expression in squamous-cell carcinoma of the head and neck was negatively cor-related with TGF-β1 expression (r=-0.32) and was positively correlated with Smad7 expression, (r=0.39), (all P<0.05).Conclusion The expression of Smad7 and Smad4 is abnormal in the squamous-cell carcinoma tissues of the head and neck, which may be involved in the invasion and differentiation by regulating EMT;The combined detections of the two expression (especially Smad4) can provide basis for clinical staging and prognosis evaluation .
Keywords：squamous-cell carcinoma of the head and neckSmad7 proteinSmad4 proteinepithelial-to-mesenchy-mal transition
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 44-46 )