Ghrelin plasma level changes and Ghrelin gene C408A polymorphism in patients with rheumatoid arthritis
YANG Mei-hua
WANG Xiang-hong
FENG Zhong-jun
MI Jiao
ZHANG Zhi-hong
Abstract：Objective To observe the Ghrelin plasma level changes and its gene C 408A polymorphism in patients with rheumatoid arthritis ( RA) and to further investigate the pathogenesis .Methods We collected the vein blood from 120 ca-ses of RA patients ( RA group) and 150 cases of healthy people ( control group ) .The plasma level of Ghrelin was deter-mined by ELISA, and the single nucleotide polymorphisms ( SNPs) of Ghrelin gene C408A were detected by PCR-RFLP method.The relationships of genotypes with the Ghrelin plasma level , course of disease, state of disease in patients with RA were analyzed.Results The plasma levels of Ghrelin in the RA group and control group were (115.03 ±38.12) and (156.28 ±65.84) pg/mL, respectively (P<0.05); significant differences were found in the genotypes and fre-quencies between the two group (all P<0.05).The plasma level of Ghrelin and course of disease were statistically differ-ent in the genotypes of CC, CA and AA in the RA group (all P<0.05), but no significant difference was found in the state of disease (P>0.05).Conclusions In RA patients, the plasma level of Ghrelin is decreased , and there is Ghrelin gene C408A mutation.Both the homozygous AA and heterozygous CA can increase the risk of RA than the wild genotype CC, but the Ghrelin gene may be not the main gene in Hebei RA patients of the Han nationality .
Keywords：rheumatoid arthritisGhrelin genesingle nucleotide polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 21-23 )