Effects of non-invasive positive pressure ventilation on arterial blood gas analysis and cytokines in patients with acute exacerbation of chronic obstructive pulmonary disease
SHEN Yang
XIAO Li
Abstract：Objective To further explore the mechanism of the non-invasive positive pressure ventilation ( NPPV) in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) .Methods Thirty cases of AECOPD patients were randomly divided into the NPPV group and control group with 15 cases in each .Patients in the two groups were given conventional treatment for AECOPD , on the basis of this , the NPPV group was treated by NPPV therapy .Before and 72 hours after treatment , the Medical Research Council Dyspnea Scale ( MRC) score and artery blood gas indexes in the two groups were evaluated , and we collected the sputum samples for determination of interleukin-6 ( IL-6), IL-8 and tumor necrosis factor-α(TNF-α) levels.Results Breathing difficulties were significantly alleviated and ar-terial blood gas results were improved in the two groups after treatment , especially in the NPPV group (all P<0.05);IL-6, IL-8 and TNF-αlevels in the sputum were decreased as compared with that before treatment in the two groups , especial-ly in the NPPV group (all P<0.05).Conclusion NPPV may reduce the systemic inflammatory response and relieve dyspnea of AECOPD patients through the inhibition of cytokines , inflammatory cells and the corresponding markers .
Keywords：non-invasive positive pressure ventilationchronic obstructive pulmonary diseaseblood gas analysisin-terleukin-6interleukin-8tumor necrosis factor-α
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )