Clinic-pathologic study of primary lymphoepithelial carcinoma in the parotid glands
Abstract：Objective To study the clinicopathologic characteristics , immunophenotype and differential diagnosis of primary lymphoepithelial carcinoma ( LEC) in the parotid glands .Methods The pathologic features of 11 parotid LEC pa-tients were collected to adopt the immunohistochemical and situ hybridization (ISH) staining test.Results LEC tumor cell present a parotid swelling feature , with sheets , islands and cords array .The tumor cells possess indistinct cell borders , lightly eosinophilic cytoplasm , oval vesicular nulei with open chromatin and conspicuous nuclei .The tumor is infiltrated by lymphocytes and plasma cells , with some accompanied by reactive lymphoid follicles .Metastases to the cervical lymph nodes were found in 5 patients and perineural invasion were found in 2 patients.CK, EMA, P63 and CK5/6 were both pos-itive and Vimentin, LCA,CD56, S-100 were negative in all 11 cases.The EBER was found positive in 10 cases by method of ISH.Conclusion LEC is a rare subtype of undiferentiated carcinoma in the parotid glands .The tumor tissue of LED was composed by malignant epithelial island and lymphoid stroma .LEC test is helpful for pathologic diagnosis of LEC .
Keywords：parotid gland tumorlymphoepithelial carcinomaEB virus
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 32-34 )