Endoplasmic reticulum stress in placentas of gestational diabetes mellitus in maternal and its influence to histomorphology of placentas
YE Zi-ying
LI Ye
ZHAO Zhen
CENG Yu-ting
LIN Jun-shan
Abstract：Objective To investigate the ralationship between endoplasmic reticulum stress ( ERS ) and damage of histomorphology of placentas in gestational diabetes mellitus (GDM).Methods Thirty women with GDM(GDM group) and 30 normal pregnan women ( control group ) were included in this study .Placentas of all women in two groups were col-lected during the delivery .The expression of phosphorylated protein kinase R-like ER kinase ( p-PERK) and CCAAT/en-hancer-binding protein homologous protein ( CHOP ) in two groups were deteced by western blot method .The features of placentas pathologicchanges were observed by using microscopy .Results The expression phosphorylated PERK and CHOP protein were significantly increased in GDM group as compared with the control group (all P<0.05).Placentas obtained from GDM group had immature villi , thickening of trunk villus small artery wall , narrowing of lumen , increasing number of syncytial sprouts , the interstitial blood capillary expanding and engorge , proliferating cytotrophoblasts and thickening of vas-culo-syncytial membrane under light microscopy .Placentas from control group did not show the pathologic changes as men-tioned above.Bivariate analysis showed that lymphatic p-PERK and CHOP expression were positively correlated with the damage of histomorphology of placentas in GDM (r=0.359, 0.366, respectively,all P<0.05).Conclusion ERS was overexpressed in placental tissue of DGM and may be positive related with the damage of histomorphology of the placentas .
Keywords：gestational diabetes mellitusplacentaendoplasmic reticulum stressphosphorylated protein kinase r-like ER kinaseCCAAT/enhancer-binding protein homologous protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 23-25 )