Relationship between polymorphisms of aldose reductase gene and type 2 diabetic retinopathy
REN Min
ZHAO Li-li
ZHANG Ying
SHI Ying
MAO Yong-min
QI Xiu-ying
Abstract：Objective To study the relationships between polymorphisms of aldose ruedctase ( AR) gene and diabetic retinopathy ( DR) among the patients with type 2 diabetes mellitu .Methods There were 161 patients with type 2 diabetic retinopathy ( case group ) and 213 patients without diabetic retinopathy ( control group ) included in this study .DNA in all patients of two groups were extracted to test the polymorphisms of AR gene -106bpC/T by polymerase chain reaction (PCR) method.PCR products were digested with restriction enzyme Bfa I .Results The frequency of CC genotype in case group (53.42%) was higher than that of control group (39.91%)(P<0.05).The frequency of C allele of AR gene in case group (71.12%) was higher than that of control group (36.15%)(P<0.05).CT/TT genotype of AR gene was associat-ed with the incidence of DR(OR=0.579, 95%CI:0.383-0.876).Type 2 diabetic patients with T allele of AR gene had low risk of diabetic retinopathy (OR=0.717, 95%CI:0.525-0.980).Conclusions The genetic polymorphism of AR C (-106 ) T is significantly associated with susceptibility of diabetic retinopathy .Type 2 diabetic patients with allele T and CT/TT genentype of AR has a lower risk of DR .
Keywords：diabetes retinopathyaldose reductasegene polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-22 )