The correlation of metabolic disorders with FABP4 in PCOS women
YIN Hong
WU Gui-fang
Abstract：Objective To study the relationship between serum FABP 4 and metabolic disorders in women with poly-cystic ovarian syndrome(PCOS).Methods Serum FABP4 levels in 76 PCOS women (consist of 50 obesity, 26 non obese) and 40 healthy volunteers as control group were detected by enzyme-linked immunosorbent assay ( ELISA) method. Serum lipid (TC,TG,HDL,LDH,ApoA1,ApoB) were observed.HOMA-IR was calculated.Oral glucose tolerance test ( OGTT) were conducted to test serum glucose level ( BG 0 h, 1 h, 2 h, 3 h) by oxidase method .The level of serum insu-lin radioimmunoassay(INS 0 h,1 h,2 h,3 h)was determined.The correlation of serum FABP4 levels and markers of meta-bolic disorders were analyzed .Results Serum FABP4 levels of PCOS groups were significantly higher than control groups , in which obese PCOS groups were significantly higher than that of non-obese PCOS groups(all P<0.05).Compared with control groups, the PCOS women had significantly higer TC,TG,LDL,BG 0 h,INS 0 h,HOMA-IR(all P<0.05).Com-pared with non-obese PCOS women, the obese PCOS women had significantly higer TC ,TG,LDL,ApoB,BG 0 h,BG 1 h, BG 2 h,INS 0 h,HOMA-IR(all P<0.05).Correlation analysis showed that serum FABP4 levels were positively correlated with TG, TC, ApoB, LDL, HOMA-IR, INS 0 h, INS 2 h(r was 0.35, 0.33, 0.26, 0.25, 0.36, 0.32, 0.32, respec-tively, all P<0.05).Conclusions PCOS women had high level of serum FABP 4 which had relationship with metabolic disorder in glucose and lipid .
Keywords：polycystic ovarian syndromemetabolic disorderfatty acid-binding proteins
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 17-19 )