Effect of PVA with portocaval shunt on iNOS in cirrhotic rat liver
CAI Chao-nong
FANG Rui-jun
LI Pei-ping
ZHANG Bai-meng
GUAN Xiao-dong
LI Jian
Abstract：Objective To evaluate the impact of inducible nitric oxide synthase ( iNOS) expression following portal vein arterializations(PVA) associated with portocaval shunt (PCS) in cirrhotic rats liver.Methods A total of 100 rats were involved to make cirrhosis model and randomly equally divided into three groups , which were group A ( adopted PVA+PCS operation), group B(PCS operation only), group C(adopted portal vein block for 30 mins and right nephrectomy oper-ation).iNOS in liver of each group was measured by method of immunohistochemistryat the moment of pre -operation, post-operative 1 week, 2 weeks,4 weeks and 8 weeks.The results were analysed by software Image-Pro Plus 6.0.Results The values of iNOS decreased obviously over time after surgery in three groups , which were significantly lower than the values of pre-operation (all P<0.05).The values of iNOS in group A were significantly higher than the other two groups at the mo-ment of postoperative 1, 2 and 4 weeks(all P<0.01).Until the moment of postoperative 8 weeks, there was no significant difference between the group A and the other two groups .Conclusions PVA with PCS technique can raise the iNOS ex-pression of liver tissues in cirrhotic rats within postoperative 4 weeks, but this reactions gradually become less obvious after postoperative 4 weeks.
Keywords：portal vein arterializationsportocaval shunthepatic cirrhosisinducible nitric oxide synthase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )