Expression of vascular endothelial growth factor soluble receptor in the serum and peritoneal fluid of EMs patients
LI Yan-fang
SHI Shu-hong
LI Teng-hua
LI Rong-xia
Abstract：Objective To detect the expression of vascular endothelial growth factor soluble receptor ( sflt-1 ) in the serum and peritoneal fluid of the EMs patients and explore it's clinical siginificance .Methods A total of 48 EMs patients including 15 ⅠtoⅡstage patients and 33ⅢtoⅣstage patients .Thirty patients cured by the laparoscopic surgery with-out EMS were involved as control group .The expressions of VEGF and sflt-1 in the serum and peritoneal fluid of the two group patients were detected by using ELISA .VEGF activity index was calculated .Results The serum and peritoneal flu-id level of VEGF and sflt-1 as well as VEGF activity index in EMs group were both higher than those of control group ( all P<0.05).The serum and peritoneal fluid level of VEGF and sflt-1 as well as VEGF activity index in stage ⅢtoⅣpatients were both higher than those of stage ⅠtoⅡpatients(all P<0.05).Conclusions Anti-angiogenic factor expression ab-normalities may be related to the pathogenesis of endometriosis .The sFlt-1 may be a new treatment targets .
Keywords：endometriosisvascular endothelial growth factorvascular endothelial growth factor soluble receptor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )