Correlation between IL-13 gene polymorphism and susceptibility to asthma
XI Su-ya
CHEN Shu-zhen
LIU Jian-qiang
ZHANG Ling
WANG Shao-ying
Abstract：Objective To investigate the correlation between the single nucleotide polymorphism ( SNP) of +1923 C/T in intron region of interleukin-13 (IL-13) gene and the susceptibility to asthma .Methods The genotypes and the allele frequency distributions of +1923 C/T SNP of IL-13 in 150 asthmatic patients and 150 healthy controls were detected by u-sing polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP) methods.Results The genotype frequencies of CC, CT and TT in +1923C/T sites of IL-13 gene were 41.33% (62/150), 44.00% (66/150) and 14.67%(22/150) respectively in the controls, and 21.33%(32/150), 41.33%(62/150) and 37.34%(56/150) in the asthmatic subjects .The distribution of genotype in +1923 C/T sites of IL-13 gene between the two groups was signifi-cantly different (χ2 =24.52, P<0.01).The CT and TT genotypes carried higher risks for asthma than CC genotype (χ2 =27.39, P<0.01).Conclusion The +1923 sites polymorphism of IL-13 gene may be an important candidate gene for asthma and the T allele in the gene might be associated with the susceptibility to asthma .
Keywords：asthmainterleukin-13polymorphismsingle nucleotidepolymerase chain reaction-restriction fragment length polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 18-20 )