Effects of different doses of ambroxol on cytokines in sputum from elderly patients with AECOPD
ZHANG Ya-nan
ZHANG Wei-bing
TIAN Xiao-yan
ZHANG Hui
ZHAO Chun-yu
Li Xiang
LIU Chang-ping
Abstract：Objective To observe the effects of different doses of ambroxol on cytokines ( IL-6, IL-8 and TNF-α) in the sputum from elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to find the minimum dose of ambroxol with the best treatment effect .Methods Totally 194 cases of elderly patients with AECOPD were selected and were randomly divided into four groups , 50 cases in each group:groups A, B, C and D.Patients in the groups A, B and C were given 30, 90 and 330 mg/sub ambroxol;patients in the group D were treated with bromhexine 4 mg/sub, three times a day;and all patients were continuously treated with intravenous infusion for seven days .The chan-ges of IL-6, IL-8 and TNF-αin each group on the first day , the forth day and the seventh day of hospitalization were ob-served.Results Compared with groups A , B and D, IL-6、IL-8 and TNF-αon the forth day and the seventh day in the group C had the greatest reduction (all P<0.05), but there were no significant differences between the forth day and the seventh day(all P>0.05).Conclusion Short-term and high-dose of ambroxol in treatment of elderly AECOPD has not only good expectorant effect but also reduces the airway inflammation of AECOPD patients , and it shows a dose-dependent manner .
Keywords：pulmonary diseasechronic obstructiveambroxolcytokines
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )