Relationships between uric acid and hypertension or electrocardiogram ischemic ST-T changes in Guangzhou policemen

WANG Jing-xuan; QU Wen-chao; ZHOU Zhi-heng; LIU Ben-rong; KANG An

doi:10.3969/j.issn.1002-266X.2014.28.004

Abstract：Objective To discuss the relationships between uric acid ( UA) and hypertension or electrocardiogram is-chemic ST-T changes of Guangzhou policemen .Methods Totally 2 120 policemen of Haizhu District of Guangzhou were di-vided into four groups according to their UA levels as following: UA<349 μmol/L was the low level group , UA 349-408μmol/L was the medium relatively low group , UA 409-472μmol/L was the medium relatively high level group and UA >472μmol/L was the high level group .The blood pressure, the incidence of ECG ischemic ST-T changes, TG, CHOL, LDL-C, HDL-C, fast blood glucose (FBG), ALT, AST, UA, creatinine (CRE) levels between those groups were compared and ana-lyzed.Results There were 335 cases suffering hypertension , whose UA levels were (445.6 ±99.2) μmol/L; and there were 1 785 cases without hypertension , whose UA levels were (406.6 ±93.5)μmol/L (P<0.01).There were 1 938 cases without ischemic ECG ST-T changes, whose UA levels were (414.9 ±93.9) μmol/L;and there were 182 cases with ische-mic ECG ST-T changes, whose UA levels were (386.0 ±106.1) μmol/L;P<0.01.Multivariate unconditional logistic re-gression analysis suggested that age , Hb, RBC, ALT, TG, UA, ST-T changes and fatty liver of B ultrosound all might be the risk factors for hypertension;DBP, GLU and AST might be the risk factors for ischemic ECG ST-T changes.Conclusions Both of the blood pressure levels and prevalence of hypertension rise with the increase of UA levels .UA may be an independ-ent factor for hypertension .Either of the low levels or high levels of UA may increase the incidence of ECG ischemic ST -T changes.But when UA reaches a certain high level , the incidence of ECG ischemic ST-T changes may decline.