Expression changes and significance of Raf kinase inhibitor protein and nuclear factor-κBp65 in gastric cardia adenocarcinoma
WEI Hong
QI Shu-jing
LIU Wen-li
XU Liang
LI Li-dong
LI Hua
DONG Zhi-ming
ZHANG Xiang-yang
Abstract：Objective To observe the expression changes of Raf kinase inhibitor protein ( RKIP) and nuclear factor-κBp65 (NF-κBp65) in gastric cardia adenocarcinoma (GCA) and to discuss the significance.Methods The expression of RKIP and NF-κBp65 in cancerous tissues ( carcinoma group ) and the paracancerous tissues ( adjacent group ) from 160 GCA patients were detected by immunohistochemistry assay .The relationships between the two indexes and with the clinical and pathological features of GCA were analyzed .Results The positive expression rates of RKIP in the cancerous tissues and paracancerous tissues were 38.75%and 52.5%, respectively;the difference was significant (P<0.01).The positive expression rates of NF-κBp65 in the two groups were 75 .625% and 20 .000%, and the difference was significant ( P<0.01).The positive expression rate of RKIP was associated with lymph node metastasis in GCA (P<0.05).The positive expression rate of NF-κBp65 was associated with clinical staging , differentiation of the cancer and lymph node metastasis (all P<0.05).Negative correlation was found between the expression of RKIP and NF-κBp65 in GCA (r=-0.431, P<0.01).Conclusions The expression of RKIP is down-regulated and NF-κBp65 is up-regulated in the GCA tissues .The invasion and metastasis of GCA are promoted by the up-regulation of NF-p65 expression and down-regulation RKIP expres-sion.
Keywords：gastric cardia adenocarcinomaRaf kinase inhibitor proteinnuclear factor-κBp65
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )