Expression changes and significance of VEGF and E-cadherin in non-small-cell lung cancer
HAO Qin
CHEN Mei-ni
Abstract：Objective To observe the expression changes of vascular endothelial growth factor ( VEGF) and E-cad-herin ( E-cad) in the tissues of non-small-cell lung cancer ( NSCLC) and to investigate the significance .Methods Immu-nohistochemical SP method was performed to detect the expression of VEGE and E -cad in 52 cases of NSCLC tissues ( ob-servation group ) and 11 benign lesion lung tissues ( control group ) .The correlations between two indexes and clinical path-ological index of NSCLC were analyzed .Results The positive expression rates of VEGF in the observation and control group were 71.15%(37/52) and 18.18%(2/11), respectively (all P<0.01).The positive expression rates of E-cad were 57.69%(30/52) and 90.91%(10/11), respectively (all P<0.05).The expression of VEGF and E-cad was cor-related with lymph node metastasis, TNM stages and differentiation degrees (all P<0.05), but was not correlated with the rest of pathological indexes (all P>0.05).Spearman rank related analysis showed that the expression of VEGF was nega-tively correlated with E-cad expression in the observation group (r=-0.373, P<0.01).Conclusions The VEGF ex-pression is up-regulated and E-cad expression is down-regulated in the NSCLC .Both of them may cooperatively participate in the occurrence and development of NSCLC .
Keywords：non-small-cell lung cancervascular endothelial growth factorE-cadherin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )