Influence of adiponectin resistance on heart valve disease and it′s molecular mechanism
REN Kai
CHENG Liang
YI Wei
ZHAO Bi-jun
WANG Xiao-wu
SU Jie
YI Ding-hua
Abstract：Objective To investigate the effect of adiponectin resistance on heart valve disease and the related resist -ance mechanism .Methods Thirty-six patients undergoing cardiopulmonary bypass ( CPB) heart valve replacement surger-y ( the treatment group ) and 22 cases of heart transplant donors who needed heart surgery ( the control group ) were select-ed.The myocardial tissues which were cut off in the cardiac operation under CPB were collected .The adiponectin expres-sion in the myocardial tissue samples was detected by RT-PCR.The adiponectin important molecular pathways downstream AMP-activated protein kinase ( AMPK) activity was detected by Western blotting .The cardiac pathology was detected by HE staining method.Results Compared with the control group , adiponectin mRNA was significantly higher , and the level of downstream pathways AMPK phosphorylation was significantly lower in the treatment group (all P<0.01).Histopathol-ogy results complied with the appropriate cardiac function of myocardial performance .Conclusion The adiponectin levels in the tissues of patients with heart valve disease are significantly increased , but adiponectin receptor AMP-activated protein kinase ( AMPK) phosphorylation levels are decreased , thus adiponectin can not play the protective effect , and myocardial tissues of patients show adiponectin resistance .
Keywords：adiponectin resistanceheart valve diseaseadiponectinAMP-activated protein kinase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 11-13 )