Relationships of thickness and types of endometria in window of implantation and leukemia inhibitory factor with outcome of in vitro fertilization and embryo transfer

doi:10.3969/j.issn.1002-266X.2014.24.002

Abstract：Objective To explore the possible relationships of thickness and types of endometria in the window of im -plantation and leukemia inhibitory factor ( LIF) in uterine flushing fluid with the outcome of in vitro fertilization and embryo transfer ( IVF-ET) .Methods A total of 105 patients with infertility who underwent in vitro fertilization ( IVF) or intracy-toplasmic sperm injection ( ICSI) were examined in the window of implantation (7-9days after ovulation ) before the previ-ous cycle of IVF-ET.The thickness and sonographic appearance of endometrium was measured by transvaginal ultrasonogra -phy, and the concentrations of LIF in uterine flushing fluid by enzyme linked immunosorbent assay (ELISA).Results Sixty-four patients were successful in pregnancy and 41 patients failed after treatment .There was no difference in age , in-fertility time and infertility type between pregnant women and non-pregnant women .The endometrial thickness in the win-dow of implantation of pregnant women was significantly less than that of non -pregnant ones [(11.89 ±1.63) mm vs (13.72 ±2.39) mm](P<0.05).The endometrial thickness was divided into three groups:7-10mm, 10-13mm and 13-17mm, and the corresponding pregnant rates were 40%, 72.73%and 41.38%.The endometrial type of 50 women was A, of 36 women was B and of 19 women was C, and the corresponding pregnant rates were 70%, 63.9%and 31.6%.There was significant difference in the pregnant rate between type A and B , between type A and C (all P<0.05), but there was no significant difference between type B and C (P>0.025).The concentration of LIF in uterine flushing fluid of pregnancy group was higher than non-pregnancy group [(41.19 ±31.02) pg/mL vs (23.43 ±23.09) pg/mL](P<0.05).Conclu-sions It is important to examine the thickness and types of endometria by transvaginal ultrasonography and the concentra -tion of LIF in uterine flushing fluid in the previous cycle of IVF-ET for the assessment of endometrial receptivity and predic-tion of IVF-ET outcome.