Meta-analysis of antiplatelet effects of aspirin and clopidogrel
QIU Shi
MIAO Feng-ru
WU Tao
LI Ji-lai
WANG Pei-fu
DU Ji-chen
Abstract：Objective To analyze the differences in the antiplatelet effects of aspirin , clopidogrel and joint application by Meta-analysis.Methods According to Meat-analysis, MEDLINE, EMbase, CCTR, CBMdisc, CNKI and VIP data-base were searched for the related randomized controlled trials (RCTs).Analysis was performed by RevMan5.2 software to study the antiplatelet effects of aspirin and clopidogrel .Results Five case-control studies were included , containing 206 cases in the aspirin group , 205 cases in the clopidogrel group and 300 cases in dual-therapy group .The platelet inhibition rate of clopidogrel group ADP ( Adenosine diphosphate ) pathway was significantly lower than that of aspirin group AA (Arachidonic acid) pathway (P<0.05); the platelet inhibition rate of aspirin group AA pathway was significantly lower than that of dual-therapy group (P<0.05);the platelet inhibition rate of clopidogrel group ADP pathway was significantly lower than that of dual-therapy group (P<0.05).Conclusions The antiplatelet effect of regular dose of aspirin is better than that of clopidogrel .Aspirin and clopidogrel have synergistic antiplatelet effect .
Keywords：aspirinclopidogrelplatelet inhibition rateMeta analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 40-43 )