Effects of emodin on lung permeability in acute lung injury in sepsis rats
LIU Jun
YANG Jie
WU Xiao-yan
CHENG Jie-jing
YANG Xiao-yan
SUN Yan-ni
Abstract：Objective To investigate the effects of emodin on lung permeability in acute lung injury in sepsis rats . Methods A total of 120 adult male SD rats were randomly divided into 6 groups:blank control group , sham group , model group, low dose, medium dose and high dose emodin pretreatment groups , with 20 rats in each group.The rats with sepsis were induced by cecal ligation and puncture (CLP).In the sham group, the abdominal cavity was closed after cecal explo-ration operation.According to the specimen collection time , each group was further divided into four time points:3 hours, 6 hours, 12 hours and 24 hours after modeling, with 5 rats in each time point.Rats were sacrificed at different time points to measure the lung wet/dry weigh ratio ( W/D) and protein concentration of the serum and bronchoalveolar lavage fluid and calculate the lung W/D and lung permeability index ( LPI) , to observe the pathological changes of lung tissue by using optical microscope and count lung injury score .Results The W/D, LPI, lung injury score in the medium and high dose emodin pretreatment groups were significantly lower than that of the model group and low dose emodin pretreatment group (all P<0.01).Conclusion Sepsis may cause pulmonary edema , which can be efficiently alleviated through early use of large doses of emodin .
Keywords：emodinsepsisacute lung injurylung permeability
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-20 )