Efficacy and safety of tetrandrine combined with 125 I seed implantation in treatment of locally advanced non-small-cell lung cancer
LIANG Ji-xiang
YANG Jing-kui
ZHENG Guang-jun
Abstract：Objective To investigate the efficacy and side-effect of tetrandrine (Tet) combined with 125I seed implan-tation in treatment of locally advanced none-small-cell lung cancer ( NSCLC) .Methods Seventy-six patients with clinical stage Ⅲa-Ⅲb NSCLC were randomly divided into two groups: the observation group and the control group , 38 in each group.All patients were treated with 125 I seed implantation guided by CT .The prescribed dose was 110 Gy.Patients in the observation group were treated with Tet 40mg 3 times per day for 3 months since 125 I seed implantation.The efficacy and toxicity of the two groups were compared .Results All 76 patients completed the seed implantation successfully .D100 was (112.4 ±12.3)Gy, D90 was (148.7 ±22.5)Gy and mean dose was (238.9 ±11.6)Gy.With the follow-up of 21 month, the total response rates of the observation group and the control group were 86 .8%and 65 .8%, 1-year survival rates were 84.2%and 63.2%, and the median survival time were 26 and 18 months respectively (all P<0.05).The major compli-cations were pneumothorax and blood sputum .Eight patients in the control group suffered 1 degree late radioactive pulmo-nary damage and none in the observation group .Conclusion Tet combined with 125 I seed implantation for locally advanced NSCLC shows good short-term effect, high local control rate, high survival rate, less complications and no obvious adverse reactions , which is worthy of clinical application .
Keywords：carcinomanon-small-cell lungradioisotopesiodinetetrandrineradiosensitization
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-18,21 )