Clinical Study of Application of FibroTest for evaluation of Different Extents of Liver Fibrosis in Patients with Chronic Hepatitis B

ZHANG Yan; WANG Chunyan; CHENG Xiaojing; LIU Guowang; HOU Wei; LUW ei

doi:10.3969/j.issn.1002-266X.2014.19.004

Abstract：Objective Objective:To investigate value of FibroTest ( FT) for the evaluation of liver fibrosis in patients with chronic hepatitis B ( CHB) .Methods :Serum specimens from 148 patients with chronic hepatitis B were tested for five indicators including α2-macroglobulin (α2M), haptoglobin (HAP), γ-glutamyl peptidase (GGT), total bilirubin (BIL) and apolipoprotein aⅠ(Apo AⅠ) and calculated the FT values according to the FT model:FT=4.467 × [lgα2M (g/L)]-1.357 ×[lgHAP (g/L)] +1.017 ×[lgGGT (U/L)] +0.0281 ×[Age(?years)] +1.737 ×lg [TBIL(? mol/L)] -1.184 ×[Apo AⅠ(g/L)]+0.301 ×sex ( male =1 , female =0 ) -5.540.The subjects were given liver biopsy during the same period .With liver biopsy as the gold standard , the ROC curves were delineated for dif-ferent endpoints .The area under the curve ( AUC) was calculated to evaluate the determinate value for liver fibrosis in pa-tients with CHB.Results:There were 4 cases in the S0-stage (the pathological stage of liver fibrosis ), 59 cases in the S1-stage, 41cases in the S2-stage, 31cases in the S3 stage and 13 cases in the S4 stage.There were 85 cases of significant fi-brosis,4 cases of severe fibrosis, and 13 cases of early cirrhosis.The FT value of the 148 patients was 0.616 ±1.152, and the FT values of fibrosis pathologic stages from S 0 to S4 were-0.326 ±0.378,-0.167 ±1.145, 0.906 ±0.834, 1.308 ± 0.516, and 1.894 ±0.544 respectively.The FT values of any 2 of the5 Stages (S0-S4) were compared, and all the P val-ues were less than 0.05.There was a positive correlation between the value of FibroTest ?? and liver pathological stage, (r=0.629, p <0.01).For the group of significant fibrosis , severe fibrosis and early cirrhosis , the AUC values of FT were 0.831, 0.889 and 0.945, the cut-off values were 0.403, 0.756 and 1.385, and the diagnostic accuracy rates were 81. 6%, 85.5%and 91.4%respectively.Conclusion:Fibro test has a certain value for the evaluation of liver fibrosis in chro-nic hepatitis .