Expression changes of CD44 v6 and E-cadherin in primary and metastatic colorectal cancer

CHEN Mei-xiang; LIU Kun-ping; LUO Feng

doi:10.3969/j.issn.1002-266X.2014.18.001

Abstract：Objective To investigate the expression changes of CD 44 v6 and E-cadherin in primary and metastatic colorectal cancer and the significance .Methods The expression of CD 44 v6 and E-cadherin proteins was detected by im-munohistochemical staining in 118 colorectal cancer tissues , 61 colorectal adenoma tissues and 41 lymph node metastasis tissues of colorectal cancer .Results The positive expression rate of CD 44 v6 protein in the colorectal cancer tissues (63.6%) was significantly higher than that in the colorectal adenoma tissues (42.6%), the positive expression rate of CD44v6 protein in Duke (C+D) (73.8%) was significantly higher than that in Duke (A+B) (50.9%), and the posi-tive expression of CD 44 v6 protein was significantly higher in the cases with metastasis than that in the cases without metasta -sis (78.0%vs 55.8%) (all P<0.05).The positive expression rate of E-cadherin protein in the colorectal adenoma tis-sues (73.8%) was significantly higher than that in colorectal cancer tissues (57.6%), the positive expression rate of E-cadherin protein in Duke (A+B) (69.8%) was significantly higher than that in Duke (C+D) (47.7%), and the posi-tive expression rate of E-cadherin protein was significantly higher in the cases without metastasis than that in the cases with metastasis (66.2%vs 41.5%) (all P<0.05).The positive expression rate of E-cadherin in 41 primary colorectal carci-nomas (41.5%) was significantly higher than that in the matched lymph node metastasis (19.5%) (P<0.05).Conclu-sion CD44 v6 protein is highly expressed in the colorectal carcinomas and the expression of E -cadherin protein is low , both of which may be associated with the invasion and metastasis of colorectal carcinoma .