Early biomarkers for prediction of contrast-induced acute kidney injury after PCI
ZHAO Zheng
LIN Wen-hua
WANG Xiao-dong
JIA Ke-gang
JING Rui
LIU Jing-jing
SONG Zhen-guo
Abstract：Objective To explore predictive effects of early biomarkers on the contrast-induced acute kidney injury (CIAKI)after PCI.Methods Totally 200 cases of patients with stable angina and acute coronary syndrome which under -went PCI were selected .According to AKI diagnostic criteria , they were divided into the AKI group (16 cases) and normal group (184 cases).The changes of plasma neutrophil gelatinase-associated lipocalin (NGAL), plasma cystatin C, urine NGAL, and urine kidney injury molecule-1 ( Kim-1) were measured before and after PCI .The area under the ROC curve ( AUC) was used to evaluate the early diagnostic value of all biomarkers for AKI .Results ① There was no significant difference in plasma NGAL, plasma cystatin C, urine NGAL and urine Kim-1 levels between the two groups before PCI (all P>0.05).②In the AKI group, the levels of biomarkers after PCI were significantly higher as compared with the levels before the operation (all P<0.01).Conclusion The biomarkers of AKI after PCI significantly increase , and can be used in the early diagnosis of AKI after PCI .
Keywords：acute kidney injuryneutrophil gelatinase-associated lipocalincystatin Ckidney injury molecule-1se-rum creatinine
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )