NF-κB expression in diffuse large B-cell lymphoma and its clinical significance
DING Kai-yang
YANG Yan
WANG Fang
ZHANG Gui-hong
WANG Zhi-hua
Abstract：Objective To investigate the expression and clinical significance of the transcription factors NF -kappa B (NF-κB) in large B cell lymphoma (DLBCL).Methods The NF-κB expression in 82 DLBCL patients was detected by immunohistochemistry , and the clinical data and survival were recorded .Results The positive expression rates of NF-κB protein were 23.53%(41/82) in GCB-DLBCL and 56.92%in non-GCB (P<0.05).The NF-κB positive expression rate of DLBCL patients had no correlation with gender , age, position, LDH, Ann Arbor stages, B symptom and non-B symptom (all P>0.05).Seventy-six cases of patients were followed up .The median survival time of GCB and non-GCB was 4-64 months and 0.5-41 months, respectively (P<0.05).Conclusion The NF-κB positive expression rate in non-GCB DL-BCL patients is higher than that of GCB DLBCL patients , and the detection of NF-κB expression helps to determine the subtypes and prognosis of DLBCL .
Keywords：diffuse large B cell lymphomaNF-kappa Bimmunohistochemistry
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 16-18 )